Published in: The Daily Star

Date: 14 Nov 2020

Hailed this week as a pandemic game-changer, the new Covid-19 vaccine offered countries that had pre-ordered doses a potential escape from a cycle of lockdowns and new waves of sickness and death.

But while richer nations plan their vaccination programmes through the end of 2021, experts warn that poorer and developing countries face hurdles that could deny billions the first proven protection against the coronavirus.

Vaccine developers Pfizer and BioNTech plan to roll out the first doses within weeks, once they receive emergency use permissions from drug agencies. They expect to have 1.3 billion doses ready next year.

The results of phase 3 clinical trials showed their mRNA vaccine was 90 percent effective in preventing Covid-19 symptoms and did not produce adverse side effects among thousands of volunteers.

At the cost of $40 per treatment, which consists of two separate shots, richer nations have rushed to order tens of millions of doses. But it is less clear what poorer nations can expect.

Anticipating the outsize demand for any approved vaccine, the World Health Organization formed the COVAX facility in April to ensure equitable distribution. COVAX brought together governments, scientists, civil society and the private sector — though Pfizer is not currently part of the facility.

Rachel Silverman, a policy fellow at the Center for Global Development, said it was unlikely that much of the first vaccine batch would end up in poorer nations.

Based on advance purchase agreements signed with Pfizer, she calculated that 1.1 billion doses had been snapped up entirely by wealthy nations.

“There’s not much left for everyone else,” she told AFP.

Some countries that pre-ordered, such as Japan and Britain, are part of COVAX, so some doses are likely to reach less developed nations through their purchase agreements. Conversely, the United States, which has 600 million doses on order, is not a COVAX member, though this may change under a Joe Biden administration.

Ethics aside, epidemiological data underscores the need for equitable vaccine distribution. This month researchers at America’s Northeastern University published research examining the link between vaccine reach and Covid-19 mortality.

They modelled two scenarios. The first, the “uncooperative allocation” scenario, hypothesised what would happen if 50 rich nations monopolised the first 2 billion doses of a vaccine.

The second saw the vaccine distributed based on a country’s population rather than its ability to pay for it.

The researchers found that the rich nation stockpiling scenario reduced Covid-19 deaths by 33 percent globally. The fair-share approach prevented 61 percent.

Even if finance for poorer nations materialises, the logistics of getting the new vaccine to everyone remains dizzying. Pfizer’s vaccine is based on mRNA, which tricks the immune system to produce viral proteins itself that are then neutralised.

It appears to be effective at bestowing protection against Covid-19, yet is extremely fragile: it must be stored at -80 degrees Celsius or else it falls apart.

“Most freezers in most hospitals anywhere in the world are -20C,” said Lang.

Silverman said maintaining the vaccine’s “ultra-cold chain” from factory to patients’ arms constituted “an enormous logistical challenge even in the West”.

There are currently more than three dozen other Covid-19 vaccine candidates in development, 11 of which are in or have completed phase 3 trials.

Most experts agree that the best route out of the pandemic would be to have several safe and effective vaccines that work in different ways, giving varying levels of protection.

Source:

https://www.thedailystar.net/world/news/poorer-nations-face-vaccine-wait-1994693